This list includes 8 Diseases that start with Z, from “Congenital Zika syndrome” to “Zoster sine herpete”. These conditions are relatively few but include high-profile infections and neurological or dermatologic disorders.

Diseases that start with Z are human medical conditions whose names begin with the letter Z. Notable examples include congenital Zika syndrome and Zoster-related shingles, both important in public health.

Below you’ll find the table with Disease, Symptoms, Causes, Treatments, and Notes.

Disease: The official or common name of the condition, so you can identify and look it up quickly.

Symptoms: The most common signs and complaints people with the disease report, useful for quick recognition.

Causes: The primary cause plus top risk factors or pathophysiology, presented briefly to explain why it occurs.

Treatments: First-line or typical management options and referral notes so you know expected next steps.

Notes: Quick clinical tips, important variants, or diagnostic flags that help you interpret the table entries.

Diseases that start with Z

NameICD CodeSymptomsCauses
Zika virus diseaseA92.5Fever, rash, conjunctivitis, joint painZika flavivirus transmitted by Aedes mosquitoes; sexual or perinatal transmission possible
Congenital Zika syndromeN/AMicrocephaly, developmental delay, seizures, vision problemsIn utero Zika virus infection during pregnancy; highest risk in early pregnancy
ZosterB02Painful localized rash, blisters, burning or shooting painReactivation of latent varicella zoster virus in nerve ganglia; risk with older age or immunosuppression
Zoster sine herpeteN/AAcute neuralgia, burning or shock-like pain, sensory changesReactivation of varicella zoster virus without visible rash; more common in older or immunosuppressed people
Zollinger-Ellison syndromeN/ASevere abdominal pain, recurrent peptic ulcers, chronic diarrheaGastrin-secreting tumor gastrinoma causing excess stomach acid; sometimes linked to MEN1
Zellweger spectrum disorderN/AHypotonia, seizures, liver dysfunction, facial differencesGenetic defects in peroxisome biogenesis from PEX gene mutations; inherited pattern
Zinc deficiencyN/APoor wound healing, hair loss, diarrhea, impaired immune responseInsufficient dietary zinc or malabsorption; risk with malnutrition or chronic illness
Zieve syndromeN/AHemolytic anemia, jaundice, abdominal pain, high triglyceridesAcute alcohol-related liver injury with hemolysis and hyperlipidemia after heavy drinking

Descriptions

Zika virus disease
Acute mosquito-borne viral illness causing fever, rash and joint pain. In pregnancy it can lead to severe fetal brain problems.
Congenital Zika syndrome
Pattern of birth defects from prenatal Zika infection that includes small head size, brain abnormalities and long-term developmental issues.
Zoster
Also called herpes zoster or shingles. Causes a painful band-like rash and may lead to chronic nerve pain.
Zoster sine herpete
Shingles without the typical skin lesions, making diagnosis harder. Presents mainly with nerve pain.
Zollinger-Ellison syndrome
Rare condition where a gastrin-producing tumor causes extreme acid production, leading to ulcers and diarrhea, often managed with acid suppression and surgery.
Zellweger spectrum disorder
Severe inherited disorder of peroxisome formation causing developmental delay, liver disease and shortened lifespan.
Zinc deficiency
Common nutritional deficiency that impairs immunity, skin health and growth. Treated with dietary changes and supplements.
Zieve syndrome
Rare complication of heavy alcohol use causing jaundice, anemia and abnormal blood fats. Improves with alcohol cessation and supportive care.
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