This list covers 18 poisons, running alphabetically from “Oleander” to “Oscillatoria.” They come from a wide range of sources, including garden plants, venomous animals, industrial chemicals, and mold that grows on stored food. Some show up in medicine cabinets and pesticide sheds, while others are simply part of the natural world around us, in gardens, forests, and ponds.

Poisons are substances that harm the body when they enter it in enough quantity, whether through eating, breathing, or skin contact. Some act within minutes, while others, like certain mushroom toxins, stay silent for days before causing damage. Ouabain has a particularly striking history: African hunters once used it to coat arrow tips for hunting large game.

Below you’ll find the table with Poison, Source, Effects, Antidote, and Description.

Poison: the common name of each substance, so you can quickly find the one you’re curious about.

Source: where the poison comes from, whether a plant, animal, mineral, or man-made chemical.

Effects: what happens to the body after exposure, from mild irritation to life-threatening symptoms.

Antidote: the treatment or substance that can counteract the poison, when one exists.

Description: a short explanation that gives you context on where the poison is found and why it matters.

Poisons

PoisonSourceEffectsAntidote
OleanderNerium oleander plant (leaves, flowers, sap)Nausea, vomiting, irregular heartbeat, can be fatalDigoxin immune Fab, activated charcoal
OpiumDried latex of the opium poppy (Papaver somniferum)Slowed breathing, sedation, coma, death in overdoseNaloxone
OxycodoneSemi-synthetic opioid painkiller derived from thebaineRespiratory depression, drowsiness, overdose deathNaloxone
OrellanineCortinarius mushrooms (e.g., fool’s webcap)Delayed kidney failure, days after eatingNo specific antidote; dialysis
OuabainSeeds and bark of African Strophanthus and Acokanthera plantsHeart arrhythmia, vomiting, cardiac arrestDigoxin immune Fab
Osmium TetroxideOxidized osmium metal, used in labsSevere eye and lung damage, blindnessNo antidote; supportive care
Oxalic AcidRhubarb leaves, spinach, and other plantsKidney damage, low blood calcium, mouth burnsCalcium gluconate
OrganophosphatesSynthetic pesticides and insecticidesOverstimulated nerves, seizures, respiratory failureAtropine and pralidoxime
OrpimentArsenic sulfide mineralVomiting, organ failure, arsenic poisoningDimercaprol (chelation therapy)
Ordeal BeanSeeds of the Calabar bean plantMuscle paralysis, seizures, cholinergic crisisAtropine
OzoneReactive gas formed from oxygen, industrial byproductLung irritation, chest pain, breathing difficultyNo antidote; oxygen and supportive care
OnionAllium cepa, a common kitchen vegetableToxic to pets: anemia and weakness; mild irritant to humansNo specific antidote for pets; veterinary care
Oak AcornsAcorns and young leaves of oak treesKidney damage, digestive upset in livestockNo specific antidote; supportive care
Octopus (Blue-Ringed)Venom glands, delivered by biteParalysis, respiratory failureNo antidote; mechanical ventilation
Oxytropis (Locoweed)Toxic rangeland plants in the Oxytropis genusNerve damage and disorientation in livestock (“locoism”)No antidote; removal from pasture
Ochratoxin AMold growing on stored grain, coffee, and dried fruitKidney damage, immune suppressionNo antidote; supportive care
Ordeal TreeBark and seeds of the Erythrophleum treeHeart and digestive toxicity, vomitingNo antidote; supportive care
OscillatoriaToxic blue-green algae blooms in freshwaterLiver damage, nerve toxicity in animalsNo antidote; supportive care

Descriptions

Oleander
A common ornamental shrub whose every part contains cardiac glycosides; even a small amount can cause dangerous heart rhythm problems if ingested.
Opium
The raw source of morphine and other opiates; historically used as a painkiller and recreational drug, it can suppress breathing to fatal levels in excess.
Oxycodone
A powerful prescription opioid used for pain relief that becomes deadly in overdose by shutting down the body’s drive to breathe.
Orellanine
A slow-acting mushroom toxin that causes no symptoms for days before triggering irreversible kidney damage, making it one of nature’s sneakiest poisons.
Ouabain
Once used as an arrow poison by African hunters, this cardiac glycoside disrupts the heart’s normal pumping rhythm.
Osmium Tetroxide
An extremely volatile industrial and laboratory compound whose vapors can damage the eyes and lungs almost instantly on contact.
Oxalic Acid
Found naturally in many leafy plants, this acid binds calcium in the body and can cause kidney failure if consumed in large amounts.
Organophosphates
A family of nerve-disrupting chemicals used in agriculture that overwhelm the nervous system by blocking an enzyme needed for normal nerve function.
Orpiment
A bright yellow arsenic-based mineral once used as a pigment and rat poison, now known to be highly toxic to humans.
Ordeal Bean
Also called the Calabar bean, its seeds contain physostigmine and were historically used in West African trials by ordeal.
Ozone
A form of oxygen that protects us high in the atmosphere but becomes a lung-damaging pollutant when breathed in at ground level.
Onion
Harmless to people in normal amounts, but onions are dangerously toxic to dogs and cats, damaging their red blood cells.
Oak Acorns
Rich in tannins, acorns and fresh oak leaves can poison grazing animals like cattle and horses if eaten in large quantities.
Octopus (Blue-Ringed)
This small but deadly octopus carries tetrodotoxin in its saliva, a nerve poison strong enough to paralyze and kill an adult human.
Oxytropis (Locoweed)
Grazing animals that eat this plant accumulate a toxin called swainsonine, leading to lasting brain and nerve damage.
Ochratoxin A
A toxin produced by fungi that contaminate stored food, linked to kidney disease with long-term low-level exposure.
Ordeal Tree
Also known as sasswood, this African tree’s toxic alkaloids were historically used in trial-by-ordeal rituals to test guilt or innocence.
Oscillatoria
A type of cyanobacteria that can bloom in ponds and lakes, releasing toxins dangerous to pets, livestock, and wildlife that drink the water.
If you think there is a missing term, let us know using the contact form.